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Article

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.

Cell reports - 24 Mar 2026

Jamaluddin Aqfan, Wyatt Rachael A, Broichhagen Johannes, Levitz Joshua, Gorvin Caroline M

Abstract excerpt

The melanocortin-2 receptor accessory protein (MRAP) family interacts with and regulates the signaling of diverse G protein-coupled receptors (GPCRs). MRAP2 modifies the signaling of three distinct GPCRs, melanocortin-4 receptor (MC4R), MC3R, and ghrelin receptor (GHSR), all essential for appetite regulation. The nature of MRAP2/GPCR complexes and whether there are shared mechanisms for complex assembly, critical...

Topics

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Adaptor Proteins, Signal Transducing
beta-Arrestin 2
HEK293 Cells
Obesity
Receptor, Melanocortin, Type 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Melanocortin, Type 4

Receptors, G-Protein-Coupled

Receptors, Ghrelin

Source

Identifiers

PMID: 41722048
DOI: 10.1016/j.celrep.2026.117018

Genes

MRAP2
GHSR
MC3R
MC4R
MRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.PMID 41722048Read ↗

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