Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.

PloS one - 1 Jan 2013

Lowther Katie M, Uliasz Tracy F, Götz Konrad R, Nikolaev Viacheslav O, Mehlmann Lisa M

Abstract excerpt

G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels required for meiotic arrest in oocytes and CNS function. Ligand-activated G protein-coupled receptors (GPCRs) signal at the cell surface and are silenced by phosphorylation and β-arrestin recruitment upon endocytosis. Some GPCRs can also signal from endosomes following...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Arrestin 2
Share to Cyclic AMP
Share to Dynamins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endocytosis

Share to HEK293 Cells

Share to Intracellular Space

Share to Protein Domains

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 23826079
DOI: 10.1371/journal.pone.0065365
PMCID: PMC3694969

Genes

GPR3
GRK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.PMID 23826079Read ↗

GPR54 Regulates ERK1/2 Activity and Hypothalamic Gene Expression in a Gαq/11 and β-Arrestin-Dependent MannerSemantic proximity Read ↗

Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.Semantic proximity Read ↗

The G <sub>s</sub> -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian OocytesSemantic proximity Read ↗

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.Semantic proximity Read ↗

Orphan GPR75: A constitutively active Gαi-coupled GPCRSemantic proximity Read ↗

The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14.Semantic proximity Read ↗

Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses.Semantic proximity Read ↗

Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).Semantic proximity Read ↗

G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.Semantic proximity Read ↗

The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis.Semantic proximity Read ↗

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.Semantic proximity Read ↗

Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.