Article

Orphan GPR75: A constitutively active Gαi-coupled GPCR

2026-07-23

Abstract excerpt

<b>Background and purpose</b> Orphan G protein-coupled receptors (GPCRs) represent a significant challenge as, due to the the absence of a known endogenous ligand, their pharmacology remain elusive. GPR75 is an orphan GPCR that has been implicated in metabolic syndrome. Loss-of-function variants of GPR75 exhibit lower body mass index and reduced risk of hepatic steatosis. CRISPR-GPR75 mice are protected against di...

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Literature Corpus work: acee30e8-a535-54d7-b568-213e6af9a7d5
DOI: 10.22541/authorea.15006480/v1

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