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Article

In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity

30 Mar 2021

Abstract excerpt

Background and Purpose Members of the GPCR family are targeted by a significant fraction of the available FDA‐approved drugs. However, the physiological role and pharmacological properties of many GPCRs remain unknown, representing untapped potential in drug design. Of particular interest are ~100 less‐studied GPCRs known as orphans because their endogenous ligands are unknown. Intriguingly, disease‐causing...

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PMID: 33784795
DOI: 10.1111/bph.15468

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