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Article

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

24 Jun 2013

Abstract excerpt

The identification of the human homologue of the yeast CST in 2009 posed a new challenge in our understanding of the mechanism of telomere capping in higher eukaryotes. The high-resolution structure of the human Stn1-Ten1 (hStn1-Ten1) complex presented here reveals that hStn1 consists of an OB domain and tandem C-terminal wHTH motifs, while hTen1 consists of a single OB fold. Contacts between the OB domains...

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PMID: 23826127
DOI: 10.1371/journal.pone.0066756

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