Article
pak2a mutations cause cerebral hemorrhage in redhead zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2007
Buchner David A, Su Fengyun, Yamaoka Jennifer S, Kamei Makoto, Shavit Jordan A, Barthel Linda K, McGee Beth, Amigo Julio D, Kim Seongcheol, Hanosh Andrew W, Jagadeeswaran Pudur, Goldman Daniel, Lawson Nathan D, Raymond Pamela A, Weinstein Brant M, Ginsburg David, Lyons Susan E
Abstract excerpt
The zebrafish is a powerful model for studying vascular development, demonstrating remarkable conservation of this process with mammals. Here, we identify a zebrafish mutant, redhead (rhd(mi149)), that exhibits embryonic CNS hemorrhage with intact gross development of the vasculature and normal hemostatic function. We show that the rhd phenotype is caused by a hypomorphic mutation in p21-activated kinase 2a...
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