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Article

Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation.

Mechanisms of development - 1 Jan 2000

Tian Yanmei, Lei Liang, Cammarano Marta, Nekrasova Tanya, Minden Audrey

Abstract excerpt

Pak4 is a member of the group B family of Pak serine/threonine kinases, originally identified as an effector protein for the Rho GTPase Cdc42. Pak4 knockout mice are embryonic lethal and do not survive past embryonic day 11.5. Previous work on Pak4 knockout mice has focused on studying the phenot...

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Share to cdc42 GTP-Binding Protein
Share to Crosses, Genetic
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Neovascularization, Pathologic

Share to p21-Activated Kinases

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Source

Identifiers

PMID: 19464366
DOI: 10.1016/j.mod.2009.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19464366-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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