Loss of arap3 drives a cerebral cavernous malformation-like phenotype in zebrafish via Krit1 interaction and RhoA dysregulation.

Abstract excerpt

Cerebral cavernous malformations (CCMs) are severe vascular anomalies characterized by abnormal cerebrovascular development, leading to profound structural and functional deficits in the brain. However, the exact underlying mechanisms driving CCM pathogenesis remain incompletely understood. In this study, we identify a zebrafish arap3 mutant that exhibits localized vascular dilation, cerebral hemorrhage, impaired...

Topics

• Animals
• Zebrafish
• Zebrafish Proteins
• Hemangioma, Cavernous, Central Nervous System
• rhoA GTP-Binding Protein
• KRIT1 Protein