Article
Semaphorin-plexin signaling guides patterning of the developing vasculature.
Developmental cell - 1 Jul 2004
Torres-Vázquez Jesús, Gitler Aaron D, Fraser Sherri D, Berk Jason D, Van N Pham, Fishman Mark C, Childs Sarah, Epstein Jonathan A, Weinstein Brant M
Abstract excerpt
Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through plexin receptors. We show that proper blood vessel pathfinding...
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