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Article

A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.

Developmental biology - 15 May 2009

Covassin L D, Siekmann A F, Kacergis M C, Laver E, Moore J C, Villefranc J A, Weinstein B M, Lawson N D

Abstract excerpt

In this work we describe a forward genetic approach to identify mutations that affect blood vessel development in the zebrafish. By applying a haploid screening strategy in a transgenic background that allows direct visualization of blood vessels, it was possible to identify several classes of mutant vascular phenotypes. Subsequent characterization of mutant lines revealed that defects in Vascular endothelial...

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Identifiers

PMID: 19269286
DOI: 10.1016/j.ydbio.2009.02.031
PMCID: PMC2791107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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