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Article

PAK4 kinase is essential for embryonic viability and for proper neuronal development.

Molecular and cellular biology - 1 Oct 2003

Qu Jian, Li Xiaofan, Novitch Bennet G, Zheng Ye, Kohn Matthew, Xie Jian-Ming, Kozinn Spencer, Bronson Roderick, Beg Amer A, Minden Audrey

Abstract excerpt

The serine/threonine kinase PAK4 is a target for the Rho GTPase Cdc42 and has been shown to regulate cell morphology and cytoskeletal organization in mammalian cells. To examine the physiological and developmental functions of PAK4, we have disrupted the PAK4 gene in mice. The absence of PAK4 led...

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Source

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Identifiers

PMID: 14517283
DOI: 10.1128/MCB.23.20.7122-7133.2003
PMCID: PMC230313

Genes

PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14517283-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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