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Article

The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein.

Protein and peptide letters - 1 Jan 2009

Fu Qing-Shan, Song Ai-Xin, Li Su-Xia, Hu Hong-Yu

Abstract excerpt

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.

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Share to Cloning, Molecular
Share to Hydrolysis
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

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Source

Identifiers

PMID: 20001906
DOI: 10.2174/092986609789839386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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