Article
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls.
Molecular pain - 17 Aug 2007
Daniels Richard L, McKemy David D
Abstract excerpt
Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below approximately 26 degrees C, thus making it an intriguing candidate as the molecular mediator of cold perception....
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