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Article

Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation.

Annual review of pharmacology and toxicology - 1 Jan 2026

Katz Ben, Gutorov Rita, Maayan Channa, Zaguri Rachel, Minke Baruch

Abstract excerpt

Sensing specific temperature ranges as noxious is crucial for protecting organisms from tissue damage. While the molecular detectors for noxious heat are well-characterized, those responsible for noxious cold detection remain elusive. The transient receptor potential vanilloid 1 (TRPV1) is a polymodal channel activated by heat, acid, and various animal and plant toxins. Due to its association with inflammatory...

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Identifiers

PMID: 40632671
DOI: 10.1146/annurev-pharmtox-062624-025423

Genes

TRPV1
TRPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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