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Article

TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2011

Park Una, Vastani Nisha, Guan Yun, Raja Srinivasa N, Koltzenburg Martin, Caterina Michael J

Abstract excerpt

TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in medium- to large-diameter sensory neurons that can be activated by extreme heat (>52°C). These features suggest that TRPV2 might be a transducer of noxious heat in vivo. TRPV2 can also be activated by hypoosmolarity or cell stretch, suggesting potential roles in mechanotransduction. To address the physiological functions of TRPV2 in...

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Source

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Identifiers

PMID: 21832173
DOI: 10.1523/JNEUROSCI.1384-09.2011
PMCID: PMC3192449

Genes

TRPV2
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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