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Article

Cold hypersensitivity increases with age in mice with sickle cell disease

3 Jun 2014

Abstract excerpt

Sickle cell disease (SCD) is associated with acute vaso-occlusive crises that trigger painful episodes and frequently involves ongoing, chronic pain. In addition, both humans and mice with SCD experience heightened cold sensitivity. However, studies have not addressed the mechanism(s) underlying the cold sensitization or its progression with age. Here we measured thermotaxis behavior in young and aged mice with...

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PMID: 24953902
DOI: 10.1016/j.pain.2014.05.030

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