Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.

doi:10.1200/JCO.2007.11.0908

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Article

Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2007

Cussenot Olivier, Azzouzi Abdel Rhamene, Nicolaiew Nathalie, Fromont Gaelle, Mangin Philippe, Cormier Luc, Fournier Georges, Valeri Antoine, Larre Stephane, Thibault Frederic, Giordanella Jean-Pierre, Pouchard Michel, Zheng Yan, Hamdy Freddie C, Cox Angela, Cancel-Tassin Geraldine

Abstract excerpt

PURPOSE: The association between common functional polymorphisms from the CYP17, CYP19, CYP1B1, and COMT genes involved in the estrogen metabolism and the risk of prostate carcinoma was evaluated. PATIENTS AND METHODS: The study investigated 1,983 white French men (1,101 patients with prostate cancer and 882 healthy controls) aged between 40 and 98 years. The different alleles and genotypes were analyzed...

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PMID: 17704407
DOI: 10.1200/JCO.2007.11.0908

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COMT

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