Article
Association of variants in estrogen-related pathway genes with prostate cancer risk.
The Prostate - 1 Jan 2013
Holt Sarah K, Kwon Erika M, Fu Rong, Kolb Suzanne, Feng Ziding, Ostrander Elaine A, Stanford Janet L
Abstract excerpt
BACKGROUND: Through mediation of estrogen receptors, estradiol has been shown to have both carcinogenic and anti-carcinogenic effects on the prostate. We performed a population-based case-control study to investigate variants in estrogen-related genes ESR1, ESR2, CYP19A1, CYP1A1, and CYP1B1 and the potential association with risk of prostate cancer (PCa). MATERIALS AND METHODS: We evaluated PCa risk conferred by...
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