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Article

Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.

PloS one - 1 Jan 2016

Brureau Laurent, Moningo Dieudonné, Emeville Elise, Ferdinand Séverine, Punga Augustin, Lufuma Simon, Blanchet Pascal, Romana Marc, Multigner Luc

Abstract excerpt

BACKGROUND: Estrogens are thought to play a critical role in prostate carcinogenesis. It has been suggested that polymorphisms of genes encoding enzymes involved in estrogen metabolism are risk factors for prostate cancer. However, few studies have been performed on populations of African ancestry, which are known to have a high risk of prostate cancer. OBJECTIVE: We investigated whether functional polymorphisms...

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PMID: 27074016
DOI: 10.1371/journal.pone.0153609
PMCID: PMC4830606

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