Article
Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population.
Cancer - 1 Oct 2003
Suzuki Kazuhiro, Nakazato Haruki, Matsui Hiroshi, Koike Hidekazu, Okugi Hironobu, Kashiwagi Bunzo, Nishii Masahiro, Ohtake Nobuaki, Nakata Seiji, Ito Kazuto, Yamanaka Hidetoshi
Abstract excerpt
BACKGROUND: Estrogen is one of the crucial hormones participating in the proliferation and carcinogenesis of the prostate glands. Genetic polymorphisms in the estrogen metabolism pathway might be involved in the risk of prostate carcinoma development. The authors evaluated the association between genetic polymorphisms in estrogen-related enzymes and receptors and the risk of developing familial prostate...
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