Article
Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial.
Carcinogenesis - 9 Feb 2018
Tang Li, Platek Mary E, Yao Song, Till Cathee, Goodman Phyllis J, Tangen Catherine M, Wu Yue, Platz Elizabeth A, Neuhouser Marian L, Stanczyk Frank Z, Reichardt Juergen K V, Santella Regina M, Hsing Ann, Figg William D, Lippman Scott M, Thompson Ian M, Ambrosone Christine B
Abstract excerpt
Substantial preclinical data suggest estrogen's carcinogenic role in prostate cancer development; however, epidemiological evidence based on circulating estrogen levels is largely null. Compared with circulating estrogen, the intraprostatic estrogen milieu may play a more important role in prostate carcinogenesis. Using a nested case-control design in the Prostate Cancer Prevention Trial (PCPT), we examined...
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