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Article

Crystal structure of an ancient protein: evolution by conformational epistasis.

Science (New York, N.Y.) - 14 Sept 2007

Ortlund Eric A, Bridgham Jamie T, Redinbo Matthew R, Thornton Joseph W

Abstract excerpt

The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucocorticoid (GR) and mineralocorticoid (MR) receptors. Using structural, phylogenetic, and functional analysis, we identify the specific set of historical mutations that recapitulate...

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Identifiers

PMID: 17702911
DOI: 10.1126/science.1142819
PMCID: PMC2519897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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