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Article

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

Nature - 14 Aug 2014

Harms Michael J, Thornton Joseph W

Abstract excerpt

Understanding how chance historical events shape evolutionary processes is a central goal of evolutionary biology. Direct insights into the extent and causes of evolutionary contingency have been limited to experimental systems, because it is difficult to know what happened in the deep past and to characterize other paths that evolution could have followed. Here we combine ancestral protein reconstruction,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Glucocorticoid

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Identifiers

PMID: 24930765
DOI: 10.1038/nature13410
PMCID: PMC4447330

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