Article

Conformational epistasis impairs AlphaFold structural predictions

2022-11-17

Abstract excerpt

Protein structures have been massively predicted using homologous sequence information. AlphaFold2 (AF2) is a recent breakthrough to predict 3D models using machine learning approaches that reached an outstanding accuracy in recent quality evaluations. However, information derived from extant homologous sequences, as those used by AF2, might not contain enough information to accurately predict protein structure. T...

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Literature Corpus work: 369ddead-90fd-53a3-850b-584dcb3e6a3f
DOI: 10.1101/2022.11.15.516638

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