Article
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.
Nature - 24 Sept 2009
Bridgham Jamie T, Ortlund Eric A, Thornton Joseph W
Abstract excerpt
The extent to which evolution is reversible has long fascinated biologists. Most previous work on the reversibility of morphological and life-history evolution has been indecisive, because of uncertainty and bias in the methods used to infer ancestral states for such characters. Further, despite theoretical work on the factors that could contribute to irreversibility, there is little empirical evidence on its...
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