Article
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013
Harms Michael J, Eick Geeta N, Goswami Devrishi, Colucci Jennifer K, Griffin Patrick R, Ortlund Eric A, Thornton Joseph W
Abstract excerpt
The genetic and biophysical mechanisms by which new protein functions evolve is a central question in evolutionary biology, biochemistry, and biophysics. Of particular interest is whether major shifts in protein function are caused by a few mutations of large effect and, if they are, the mechanisms that mediate these changes. Here we combine ancestral protein reconstruction with genetic manipulation and explicit...
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