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Article

A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain.

Journal of molecular biology - 6 Aug 2004

Folkertsma Simon, van Noort Paula, Van Durme Joost, Joosten Henk-Jan, Bettler Emmanuel, Fleuren Wilco, Oliveira Laerte, Horn Florence, de Vlieg Jacob, Vriend Gerrit

Abstract excerpt

Literature studies, 3D structure data, and a series of sequence analysis techniques were combined to reveal important residues in the structure and function of the ligand-binding domain of nuclear hormone receptors. A structure-based multiple sequence alignment allowed for the seamless combination of data from many different studies on different receptors into one single functional model. It was recently shown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15276826
DOI: 10.1016/j.jmb.2004.05.075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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