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Article

Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.

PLoS genetics - 1 Jun 2011

Carroll Sean Michael, Ortlund Eric A, Thornton Joseph W

Abstract excerpt

Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies. Ancestral sequence reconstruction (ASR) offers an experimental approach to these questions. Here we use ASR to shed light on the earliest functions and evolution of the glucocorticoid receptor (GR), a steroid-activated transcription factor that plays a key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21698144
DOI: 10.1371/journal.pgen.1002117
PMCID: PMC3116920

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