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Article

Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.

PLoS genetics - 1 Jan 2014

Bridgham Jamie T, Keay June, Ortlund Eric A, Thornton Joseph W

Abstract excerpt

An important goal in molecular evolution is to understand the genetic and physical mechanisms by which protein functions evolve and, in turn, to characterize how a protein's physical architecture influences its evolution. Here we dissect the mechanisms for an evolutionary shift in function in the mollusk ortholog of the steroid hormone receptors (SRs), a family of biologically essential transcription factors. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24415950
DOI: 10.1371/journal.pgen.1004058
PMCID: PMC3886901

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