Article

The multimerization pathway of the glucocorticoid receptor

2024-12-12

Abstract excerpt

The glucocorticoid receptor (GR) is a leading drug target due to its anti-inflammatory and immunosuppressive roles. The functional oligomeric conformation of full-length GR (FL-GR), which is key for its biological activity, remains disputed. Here we present a new crystal structure of agonist-bound GR ligand-binding domain (GR-LBD) comprising eight copies of a non-canonical dimer. The biological relevance of this d...

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Literature Corpus work: 1d419a73-202e-5a28-9d3d-c53f4ef81500
DOI: 10.1101/2024.12.12.628195

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