Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.

Neurotoxicology - 1 May 2007

Morahan Julia M, Yu Bing, Trent Ronald J, Pamphlett Roger

Abstract excerpt

Sporadic amyotrophic lateral sclerosis (SALS) causes progressive muscle weakness because of the loss of motor neurons. SALS has been associated with exposure to environmental toxins, including pesticides and chemical warfare agents, many of which are organophosphates. The enzyme paraoxonase 1 (PON1) detoxifies organophosphates and the efficacy of this enzyme varies with polymorphisms in the PON1 gene. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Aryldialkylphosphatase
Share to Environment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environmental Pollutants

Share to Haplotypes

Share to Organophosphates

Share to Pesticides

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 17204329
DOI: 10.1016/j.neuro.2006.11.007

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.PMID 17204329Read ↗

Genetic susceptibility to environmental toxicants in ALS.Semantic proximity Read ↗

Paraoxonase gene polymorphisms and sporadic ALS.Semantic proximity Read ↗

Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS.Semantic proximity Read ↗

Paraoxonase cluster polymorphisms are associated with sporadic ALS.Semantic proximity Read ↗

Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.Semantic proximity Read ↗

Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease.Semantic proximity Read ↗

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.Semantic proximity Read ↗

A common haplotype within the PON1 promoter region is associated with sporadic ALS.Semantic proximity Read ↗

The -A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

Paraoxonase gene mutations in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.