Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS.

Neurology - 18 Mar 2008

Wills A-M, Landers J E, Zhang H, Richter R J, Caraganis A J, Cudkowicz M E, Furlong C E, Brown R H

Abstract excerpt

OBJECTIVE: Four recent studies report a genetic association of the paraoxonase locus with sporadic amyotrophic lateral sclerosis (ALS). We tested the hypothesis that this association correlates with functional changes in paraoxonase 1 (PON1, MIM 168820). METHODS: Sera from 140 ALS participants; 153 age-, race-, and sex-matched controls; and 30 matched CSF samples were tested for paraoxonase, diazoxonase, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carboxylic Ester Hydrolases

Share to Down-Regulation

Share to Enzyme Activation

Share to Hydrolysis

Share to Isoenzymes

Share to Organophosphates

Source

Identifiers

PMID: 18347314
DOI: 10.1212/01.wnl.0000305956.37931.dd

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS.PMID 18347314Read ↗

Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.Semantic proximity Read ↗

A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Paraoxonase gene mutations in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.Semantic proximity Read ↗

Paraoxonase 1 in neurological disorders.Semantic proximity Read ↗

Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates.Semantic proximity Read ↗

Paraoxonase gene polymorphisms and sporadic ALS.Semantic proximity Read ↗

Paraoxonase cluster polymorphisms are associated with sporadic ALS.Semantic proximity Read ↗

Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis.Semantic proximity Read ↗

Decreased serum arylesterase activity in autism spectrum disorders.Semantic proximity Read ↗

Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.