Article
Cell-cycle inhibitor profiling by high-content analysis.
Advances in experimental medicine and biology - 1 Jan 2007
Gasparri Fabio, Ciavolella Antonella, Galvani Arturo
Abstract excerpt
The discovery of agents which disrupt cancer cell division by specifically targeting key components of the cell-cycle machinery represents a major focus of recent drug discovery efforts in Oncology. The drug discovery process can be greatly enhanced by multiparametric cellular analysis which can assist in confirmation, often in a few multiplexed assays, of the mechanism of action (MOA) of compounds identified...
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