Article
Large-scale cytological profiling for functional analysis of bioactive compounds.
Molecular bioSystems - 1 Nov 2013
Woehrmann Marcos H, Bray Walter M, Durbin James K, Nisam Sean C, Michael Alicia K, Glassey Emerson, Stuart Joshua M, Lokey R Scott
Abstract excerpt
Cytological profiling (CP) is an unbiased image-based screening technique that uses automated microscopy and image analysis to profile compounds based on numerous quantifiable phenotypic features. We used CP to evaluate a library of nearly 500 compounds with documented mechanisms of action (MOAs) spanning a wide range of biological pathways. We developed informatics techniques for generating dosage-independent...
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