Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-content assays in oncology drug discovery: opportunities and challenges.

IDrugs : the investigational drugs journal - 1 Jun 2008

Mouchet Elizabeth H, Simpson Peter B

Abstract excerpt

High-content screening (HCS), a process that combines fluorescence microscopic imaging and automated image analysis, has had a significant impact on drug discovery since its introduction in the mid 1990s. The application of HCS within pharmaceutical drug discovery has become widespread, notably within oncology drug discovery. The trends, challenges and considerations for HCS that affect the successful and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Drug Design
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Source

Identifiers

PMID: 18509783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-content assays in oncology drug discovery: opportunities and challenges.PMID 18509783Read ↗

Image-based high-content screening in drug discovery.Semantic proximity Read ↗

Increasing the Content of High-Content Screening: An Overview.Semantic proximity Read ↗

A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators.Semantic proximity Read ↗

[High content screening in chemical biology: overview and main challenges].Semantic proximity Read ↗

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.Semantic proximity Read ↗

Cell-cycle inhibitor profiling by high-content analysis.Semantic proximity Read ↗

High-content assays for characterizing the viability and morphology of 3D cancer spheroid cultures.Semantic proximity Read ↗

Next-generation phenotypic screening.Semantic proximity Read ↗

Challenges and the Advancement in High-Throughput Screening Strategies for Cancer TherapeuticsSemantic proximity Read ↗

Selection of Optimal Cell Lines for High-Content Phenotypic Screening.Semantic proximity Read ↗

Improving Phenotypic Measurements in High-Content Imaging ScreensSemantic proximity Read ↗

High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug DiscoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.