Article

A Scalable 3D High-Content Imaging Protocol for Measuring a Drug Induced DNA Damage Response Using Immunofluorescent Sub-nuclear γH2AX Spots in Patient Derived Ovarian Cancer Organoids

2022-09-17

Abstract excerpt

<h4>ABSTRACT</h4> The high morbidity rate of ovarian cancer has remained unchanged during the past four decades, partly due to lack of understanding of disease mechanisms and difficulties in developing new targeted therapies. Defective DNA damage detection and repair is one of the hallmarks of cancer cells and is a defining characteristic of ovarian cancer. Most in vitro studies to date, involve viability measure...

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Literature Corpus work: 2069d1e4-e5f7-5736-9ef2-ec5e7738b9f4
DOI: 10.1101/2022.09.15.508096

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