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Linking phenotypes and modes of action through high-content screen fingerprints.

Assay and drug development technologies - 1 Sept 2015

Reisen Felix, Sauty de Chalon Amelie, Pfeifer Martin, Zhang Xian, Gabriel Daniela, Selzer Paul

Abstract excerpt

High-content screening (HCS) is a powerful technique for monitoring phenotypic responses to treatments on a cellular and subcellular level. Cellular phenotypes can be characterized by multivariate image readouts such as shape, intensity, or texture. The corresponding feature vectors can thus be defined as HCS fingerprints that serve as a powerful biological compound descriptor. Therefore, clustering or...

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PMID: 26258308
DOI: 10.1089/adt.2015.656

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