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Article

Different roles of pummelo furanocoumarin and cytochrome P450 3A5*3 polymorphism in the fate and action of felodipine.

Current drug metabolism - 1 Aug 2007

Guo Lian-Qing, Chen Qiao-Yun, Wang Xuan, Liu Yu-Xiu, Chu Xiao-Man, Cao Xiao-Mei, Li Jin-Heng, Yamazoe Yasushi

Abstract excerpt

OBJECTIVE: Herein we aim to test if pummelo furanocoumarins can inhibit cytochrome P450 (CYP) 3A both in vitro and in vivo, and to explore the influence of CYP3A5*3 (GenBank AC005020: A22893-->G) polymorphism in the pharmacokinetics and pharmacological response to felodipine. METHOD: Fruit juices of pummelo grapefruit (Citrus paradisi Macf., G), 'Guanximiyou' (C. grandis Osbeck vs. Guanxi, P) and 'Changshanhuyou'...

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Identifiers

PMID: 17691921
DOI: 10.2174/138920007781368917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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