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Article

Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions.

European journal of clinical pharmacology - 1 Sept 2014

Snyder Ben D, Rowland Andrew, Polasek Thomas M, Miners John O, Doogue Matthew P

Abstract excerpt

OBJECTIVE: To evaluate felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions (PK-DDIs) involving cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp). METHODS: Felodipine extended-release 10 mg was administered daily to six healthy subjects for 7 days (days 1-7). Subjects were administered a modified Inje cocktail comprising the selective probe substrates caffeine 100 mg (CYP1A2),...

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Identifiers

PMID: 25028073
DOI: 10.1007/s00228-014-1716-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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