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Article

Impact of 14 types of genetic polymorphisms on antihypertensive efficacy of felodipine in healthy Chinese subjects .

International journal of clinical pharmacology and therapeutics - 1 Jul 2020

Yuan Zi-Qing-Yun, Zhang Hong-Wen, Yu Zi-Dan, Tian Yuan, Sun Lu-Ning, Xie Li-Jun, Chen Juan, Meng Ling, Zhang Zun-Jian, Zhang Xue-Hui, Wang Yong-Qing

Abstract excerpt

OBJECTIVE: This study evaluated different influences of 14 single nucleotide polymorphisms (SNPs) and demographic factors leading to individual differences in the antihypertensive efficacy of felodipine in healthy Chinese subjects. MATERIALS AND METHODS: 24 subjects were sequenced for candidate SNPs. Plasma samples were obtained as clinical trial protocol, and were determined by a HPLC-MS/MS method....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to Calcium Channels, L-Type

Share to Cytochrome P-450 CYP3A

Share to Polymorphism, Single Nucleotide

Share to Tandem Mass Spectrometry

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PMID: 32301702
DOI: 10.5414/CP203686

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