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Article

Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort.

European journal of clinical pharmacology - 1 Jun 2009

Zhao Ying, Zhai Desheng, He Hui, Li Tingting, Chen Xijing, Ji Hui

Abstract excerpt

PURPOSE: Our objective was to study the effects of polymorphic the CYP3A5 (allele *1 and *3), MDR1 [single nucleotide polymorphisms (SNPs) G2677T, C3435T] and CACNA1C (SNPs rs2239128, rs2239050, rs2238032) genes on nimodipine oral disposition and response in healthy Chinese subjects. METHODS: Pharmacokinetics and pharmacodynamics data were obtained from a bioequivalence study, and the same 20 subjects were...

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Share to Administration, Oral
Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Calcium Channel Blockers
Share to Calcium Channels, L-Type
Share to Cytochrome P-450 CYP3A
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PMID: 19205682
DOI: 10.1007/s00228-009-0619-6

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