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Article

Influence of CYP3A5 and MDR1 genetic polymorphisms on urinary 6 beta-hydroxycortisol/cortisol ratio after grapefruit juice intake in healthy Chinese.

Journal of clinical pharmacology - 1 Jul 2010

Li Dan, Abudula Aziguli, Abulahake Muhutar, Zhu An-Ping, Lou Ya-Qing, Zhang Guo-Liang

Abstract excerpt

Interindividual variability of cytochrome P450 (CYP) 3A inhibition by grapefruit juice was investigated in relation to CYP3A5 and multidrug resistance gene (MDR) 1 genetic polymorphisms in Chinese Han, Uygur, and Kazakh healthy subjects. The measurement of urinary 6 beta-hydroxycortisol/cortisol ratio was used to evaluate CYP3A activity in vivo by high-performance liquid chromatography. CYP3A5*3 and MDR1 C1236T,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20160155
DOI: 10.1177/0091270009354997

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