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Article

The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers.

Journal of clinical pharmacy and therapeutics - 1 Jun 2017

Xiang Q, Li C, Zhao X, Cui Y M

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: The role of CYP3A5 in drug metabolism has been receiving attention because CYP3A5 may be more involved in the metabolism of CYP3A substrates in vivo than previously thought. The polymorphism of transporters, such as P-gp (P-glycoprotein) and breast cancer-related protein (BCRP), influences the metabolism of these substrates, and felodipine is a substrate of P-gp. The aim of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28244604
DOI: 10.1111/jcpt.12505

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