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Article

Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers.

European journal of clinical pharmacology - 1 Nov 2014

Zhou Li-Ping, Tan Zhi-Rong, Chen Hao, Guo Dong, Chen Yao, Huang Wei-Hua, Wang Lian-Sheng, Zhang Guo-Gang

Abstract excerpt

PURPOSE: Itopride is an effective gastroprokinetic agent mainly used for the treatment of functional dyspepsia. Flavin-containing monooxygenase 3 (FMO3) has been confirmed to be the key enzyme involved in the main itopride metabolic pathway. We investigated whether the FMO3 genotypes can affect itopride metabolism in Chinese healthy volunteers. METHODS: Twelve healthy volunteers who had been genotyped for FMO3...

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Source

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PMID: 25224784
DOI: 10.1007/s00228-014-1724-8

Genes

FMO3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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