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Article

Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine.

Clinical pharmacology and therapeutics - 1 Feb 2008

Hynninen V-V, Olkkola K T, Bertilsson L, Kurkinen K, Neuvonen P J, Laine K

Abstract excerpt

This study investigated the effect of terbinafine and voriconazole on the pharmacokinetics of venlafaxine in healthy volunteers. Plasma concentrations of venlafaxine and O-desmethylvenlafaxine (ODV) were measured after ingestion of 75 mg venlafaxine without pretreatment (control), after terbinafine pretreatment, or after voriconazole pretreatment. During the terbinafine phase, the area under the plasma...

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Source

Identifiers

PMID: 17687273
DOI: 10.1038/sj.clpt.6100311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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