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Article

Effects of CYP2D6 Genotypes on Venlafaxine Metabolism in Japanese Psychiatric Patients With Depression.

Therapeutic drug monitoring - 1 Oct 2021

Komahashi-Sasaki Hazuki, Yasui-Furukori Norio, Sasaki Taro, Shinozaki Masataka, Hayashi Yuki, Kato Kazuko, Inoue Yoshimasa, Tsuchimine Shoko, Watanabe Takashi, Sugawara Norio, Shimoda Kazutaka

Abstract excerpt

BACKGROUND: Venlafaxine (VEN) is primarily metabolized by CYP2D6. Although several studies have reported the significant effects of CYP2D6 on VEN and O-desmethylvenlafaxine (ODV) pharmacokinetics in Whites, limited data are available regarding the effects of the Asian-specific CYP2D6 genotype on VEN metabolism. This study evaluated the effects of the CYP2D6*10 and CYP2D6*5 genotypes on the steady-state plasma...

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Share to Antidepressive Agents, Second-Generation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33306568
DOI: 10.1097/FTD.0000000000000854

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