Article
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms.
Pharmaceutical research - 1 Apr 2024
Shen Chaozhuang, Yang Hongyi, Shao Wenxin, Zheng Liang, Zhang Wei, Xie Haitang, Jiang Xuehua, Wang Ling
Abstract excerpt
BACKGROUND: Venlafaxine (VEN) is a commonly utilized medication for alleviating depression and anxiety disorders. The presence of genetic polymorphisms gives rise to considerable variations in plasma concentrations across different phenotypes. This divergence in phenotypic responses leads to notable differences in both the efficacy and tolerance of the drug. PURPOSE: A physiologically based pharmacokinetic (PBPK)...
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