Article

Herb-drug interaction between Zuojin Pill and venlafaxine in healthy volunteers

2024-01-31

Abstract excerpt

<h4>Aims: </h4>: To evaluate the interaction between Zuojin Pill (ZJP), a Chinese herbal formula preparation and antidepressant agent venlafaxine in healthy volunteers. <h4>Methods:</h4> Here, the potential pharmacokinetic interaction between ZJP and VEN was investigated. In eleven healthy male volunteers with CYP2D6*1/*1 genotypes, the pharmacokinetics of VEN (oral administration of 25 mg per individual) were com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f90e06f1-ee5f-505a-9d0b-67c2f28407f1
DOI: 10.22541/au.170668472.27853616/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Herb-drug interaction between Zuojin Pill and venlafaxine in healthy volunteersDOI 10.22541/au.170668472.27853616/v1Read

Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms.Semantic proximity Read

Effects of the Chinese herbal formula "Zuojin Pill" on the pharmacokinetics of dextromethorphan in healthy Chinese volunteers with CYP2D6*10 genotype.Semantic proximity Read

Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine.Semantic proximity Read

PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug-drug interactions with clarithromycin and paroxetine.Semantic proximity Read

Review of the pharmacokinetics, pharmacogenetics, and drug interaction potential of antidepressants: focus on venlafaxine.Semantic proximity Read

Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions.Semantic proximity Read

CYP2D6 Phenotype Influences Pharmacokinetic Parameters of Venlafaxine: Results from a Population Pharmacokinetic Model in Older Adults with Depression.Semantic proximity Read

Effect of CYP2D6 variants on venlafaxine metabolism in vitro.Semantic proximity Read

Interactions between herbs and conventional drugs: overview of the clinical data.Semantic proximity Read

The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes.Semantic proximity Read

Effects of CYP2D6 Genotypes on Venlafaxine Metabolism in Japanese Psychiatric Patients With Depression.Semantic proximity Read

Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans.Semantic proximity Read