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Article

Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood.

Forensic science international - 10 Jan 2012

Kingbäck Maria, Karlsson Louise, Zackrisson Anna-Lena, Carlsson Björn, Josefsson Martin, Bengtsson Finn, Ahlner Johan, Kugelberg Fredrik C

Abstract excerpt

Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme CYP2D6 to the active metabolite O-desmethylvenlafaxine (ODV). VEN is also metabolized to N-desmetylvenlafaxine (NDV) via CYP3A4. ODV and NDV are further metabolized to N,O-didesmethylvenlafaxine (DDV). VEN is a racemic mixture of the S- and R-enantiomers and these have in vitro displayed different degrees of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21840145
DOI: 10.1016/j.forsciint.2011.07.034

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