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Article

Effect of cytochrome P450 enzyme polymorphisms on pharmacokinetics of venlafaxine.

Therapeutic drug monitoring - 1 Feb 2011

McAlpine Donald E, Biernacka Joanna M, Mrazek David A, O'Kane Dennis J, Stevens Susanna R, Langman Loralie J, Courson Vicki L, Bhagia Jyoti, Moyer Thomas P

Abstract excerpt

This study examines the relationship between blood concentrations of venlafaxine and its active metabolite, O-desmethyl venlafaxine (ODV), and genetic variants of the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human subjects. Trough blood concentrations were measured at steady state in patients treated with venlafaxine extended release in a clinical practice setting. CYP2D6 and CYP2C19 genotypes were converted...

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PMID: 21099743
DOI: 10.1097/FTD.0b013e3181fcf94d

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